Calcium Hydroxylapatite
Calcium Hydroxylapatite is one of the most well-studied dermal fillers worldwide and has been substantially used for the correction of moderate-to-severe facial lines and folds as well as lost volume due to aging.
It is a naturally-occurring substance found in our bones. These type of fillers are also soft and gel-like. The consistency is thicker than Hyaluronic Acid fillers, meaning Calcium Hydroxylapatite fillers will last longer than Hyaluronic Acid fillers. Typically, they last 12 months.
Calcium Hydroxylapatite also helps stimulate natural collagen production, a naturally-occurring substance in the skin that provides structure and firmness. Calcium Hydroxylapatite is typically used for deeper lines and wrinkles.
FDA approved CaHA fillers include Radiesse®.
Minor Clarification
While CaHA is naturally occurring in bones, the filler material itself is synthetically produced to ensure biocompatibility and reduce allergy risks[2].
Citations:
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295857/
[2] https://www.plasticsurgery.org/cosmetic-procedures/dermal-fillers/types
[3] https://www.mdpi.com/2079-9284/11/2/61
[4] https://pubmed.ncbi.nlm.nih.gov/24002146/
[5] https://emedicine.medscape.com/article/1125066-overview
[6] https://www.health.harvard.edu/blog/dermal-fillers-the-good-the-bad-and-the-dangerous-201907152561
[7] https://www.oaepublish.com/articles/2347-9264.143563
[8] https://www.asds.net/skin-experts/skin-treatments/injectables/injectable-calcium-hydroxylapatite